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The medications used for treatment of ankylosing spondylitis are relatively safe, but they need close monitoring. If you are taking non-steroidal, you need intermittent blood testing to make sure it’s not affecting your kidneys or the liver. It is also important to avoid non-steroidal if you have underlying kidney disease or liver disease. Prior to starting any biologic treatment, it is important to test for underlying tuberculosis or hepatitis. A regular follow-up with your rheumatologist will help identify any potential side effects and prevent long-term complications.