"There are numerous causes of eczema so it is difficult to pinpoint one exact cause. Some causes of eczema include the following: genetic risk factors, family or personal predisposition to the disease, environmental influences and presence of the atopic triad, including allergic rhinitis and asthma. The full pathogenesis has not been fully elucidated, but involves an immune mechanism. The exact cause of atopic dermatitis and eczema is a feature we're trying to accomplish every day. The mechanism behind the pathogenesis of atopic dermatitis can be classified into broad categories, such as immune dysregulation, dysfunction of the epidermal skin barrier and alteration of the skin's microbiome. Each of these categories can be strongly influenced by environmental and genetic factors. It topic dermatitis is linked to the presence of IgE antibodies that are allergen specific that exist in about 70% of individuals that meet diagnostic criteria for atopic dermatitis the hygiene hypothesis proposes that individuals exposed to less microbes and infectious agents earlier in life have an increased predisposition to atopic disorders. Both genetic and environmental triggers, such as microbial colonization, irritation of the skin and cutaneous sensitization have important roles in the pathogenesis of atopic dermatitis.
A loss of function variant in the [?] gene encodes a protein important to the epidermal barrier function and is present in 25 to 50% of patients of Asian and European descent, and are also implicated in ichthyosis vulgaris. There are many triggers of atopic dermatitis, multiple psychological, genetic and environmental factors can exacerbate or trigger eczema. Avoiding relevant triggers is an important consideration in the management of atopic dermatitis."
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