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Another cause of aseptic loosening of the knee replacement is a process called osteolysis. This is due to older generation implants where the plastic has been worn down completely, creating a particular debris that gets debonded into the bone itself and actually creates this license of the bone, where different enzymes in our bodies then create a destructive process of the bone and debond the implant bone interface. This makes the implant no longer viable to the bone and subject to migration and loosening of the implant.