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The symptoms of menopause are definitely associated with other conditions being loss of bone mineral density or osteoporosis, cardiovascular disease and stroke, weight gain, autoimmune issues and autoimmune disorders, skin, hair, nail changes, crepiness of the skin, moodiness. Our mood is really impacted by hormone imbalance and the absence of estrogen. 90% of women. Handful of women that float through menopause, no big deal, but that’s the exception, not the rule. Most all women will experience mood changes during menopause.