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Shingles is also known as herpes zoster, which is typically a localized blistering and painful rash caused by a reaction of the varicella zoster virus. Herpes zoster is characterized by a dermatomal distribution. The blisters are typically localized to one distribution of one to two adjacent sensory nerves. The rash is usually unilateral with a sharp cutoff at the interior and posterior midlines. Herpes zoster is also known as shingles varicella. Zoster virus is also known as human herpes virus three, and is also a member of the herpesveridae family of double-stranded DNA viruses.