There is a family form of having ulcers. This is not necessarily the most common cause of ulcers. There are other conditions by which patients can have multiple ulcers, and these are more difficult to treat. Sometimes it also runs in families, but on average, two thirds of all ulcers are caused by that bacterium H. Pylori. The other third related to the NSAIDs those aspirin, Motrin, Aleve, Ibuprofen type medications. The other causes of ulcers, 1% or less.