If a patient does not improve with splinting or depending on the severity of their symptoms in the carpal tunnel, one option would be to give them a cortisone injection. The cortisone injection is given into the region of the carpal tunnel. The cortisone is an anti-inflammatory and it can help settle down the inflammation in the carpal tunnel. It can be actually quite helpful for carpal tunnel syndrome. I’ve had many patients who had complete resolution of their symptoms with one cortisone injection.