A lot of people with type 2 diabetes wonder if they can ever come off of the medications. Once theyÕve started on medications, can they ever stop? The good news is that for many patients, the answer is Òyes.Ó Especially shortly after diabetes has been diagnosed (in the first ten years or so) if a person loses weight, they can often come off of their medication. ThatÕs the really good news Ð you can do something about it. Some people (especially people who have had type 2 diabetes for a long time) they will always need some kind of medication and even weight loss wonÕt change things at that point. But many people can come off of their medications just by losing weight.