There is a small segment of the population, about 5% where their low back pain does not respond well to conservative management or the diagnosis of the back pain is an emergent diagnosis such as certain fractures in the spine, or compressions of certain nerves in the spine. And those would result in surgical intervention where the patient would have a decompression, possibly a fusion. A decompression is where you reduce the pressure on the nerves that are coming out of the spine, in order for those nerves to effectively wake up and reactivate and start working again. If you have a compression of any of those nervous for any prolonged period of time, there is a potential of strangulating the nerve where there’s irreparable damage. And even with surgical intervention, the patient may not recover.