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Other than the inconvenience of coming in every 3 months, you also have to consider that Depo-Provera is an appetite stimulant, meaning that it can make people hungry and some people can gain weight on it. In addition, even when you stop the shot, it can last in your system for up to a year, meaning if you decide that you’d the shot to get pregnant, your fertility may take a while to resume. Also, you may have irregular bleeding with the Depo-Provera shot. Sometimes people have persistent bleeding with each injection and/or sometimes you may have no period at all.