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Carpal tunnel is compression of the median nerve at the carpal tunnel, which is a ligament that overlies nine tendons and the median nerve in the palm. What happens is that the median nerve gets compressed by this ligament called the transverse carpal ligament, which is a ligament overlying the tendons and the nerve. With certain activities – for instance, someone working with a jackhammer or even someone just working at a desk – if their nerve gets irritated, the transverse carpal ligament can compress the nerve and cause numbness and tingling in the thumb, index finger, middle finger, and ring finger.