Chronic sinusitis is often treated with a class of medications known as corticosteroids, which reduce inflammation and swelling in the affected tissue. Reducing swelling and inflammation will allow sinuses to drain and pressure to be relieved. Anti-histamines and decongestants also may be given to reduce swelling and if a bacterial infection is suspected, an antibiotic will be given. Some of the medication can be administered orally. However, sometimes they may be given topically, as a nasal spray.
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