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The patient’s quality of life with urticaria is severely impaired. Consequently, management of disease should be expeditious. Trigger factors should be avoided. Underlying disease should be identified and controlled if possible, and aggressive pharmacologic treatment instituted. Although there is no cure, the attempt to have symptom-free contracts should be of highest importance. This can be achieved with vitamin D3 correction, behavioral modification, anti-histamines and anti IgE monoclonal antibodies. Xolair, and [?] being of note or the importance.