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Berberine is one of the best studied alternative treatments for diabetes. It’s derived from plants like Golden Seal and Oregon Grape, and it’s been used in Chinese medicine for thousands of years. One recent study in 2008 showed that Berberine was as effective as Metformin for lowering hemoglobin A1c and fasting glucose, but Berberine actually outperformed Metformin in the same study for lowering cholesterol and triglycerides.