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Genetics – Polygenic Risk Score

February 24, 2021


Polygenic risk scores have been recently popularized in the field of genomics, because they provide a convenient way to be able to take all the different studies and findings for particular gene variants and combine them into one equation that will allow you to use those different gene variants to predict what the phenotype is likely to be. So basically you take all the results of those studies and add a coefficient or a weight using statistics or statistical methods. So in essence, that becomes the next big frontier in this area of genomics. The ability to use phenotypic characteristics is inputs into the models. Not only outputs. Will allow us to make the equations and their prediction even more powerful and applicable to various clinical situations.

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