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As leukemia cells replace the normal blood in bone marrow cells, patients ultimately develop low blood counts that can lead to specific symptoms. For example, low red blood cells or anemia can cause fatigue or tiredness. Low white blood cells can lead to frequent or severe infections. And low platelet counts can lead to easy bleeding or bruising. Some patients may also experience loss of appetite and therefore loss of weight as well as fevers or drenching night sweats.