Surgical management of Pituitary adenomas. If it’s determined that a tumor should be removed surgically, a pituitary tumor and typically, we are talking about pituitary adenomas, the indications for surgery we sort of already discussed, but primarily would be one of two indications. Tumor is big and pushing on things. And typically that would be the optic apparatus. So some sort of visual threat may be involved here, or maybe the tumor is big, patient is young and we’re worried that the growth rate of the tumor would lead to future visual threat. So that’s one reason. Another reason would be a hormonally active tumor that can’t be treated with medication.