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In some cases of preterm labor, we do not know exactly what are the causes of it to happen. For some women, there are certain issues that can lead to preterm labor, such as over-distension of the uterus, which is common in the case of pregnancy that are multiple. Stress may be a factor that can lead to preterm labor, as well as mental distress or emotional distress in the mom. One of the signs are vaginal bleeding that are signals to the body, as well as infection or inflammation may be a cause of preterm labor.