For many patients, the initial treatment of Sciatica is with nonsteroidal anti-inflammatory drugs. In trade names, Aleve, and Ibuprofen, and Motrin and Advil, and these can help a majority of patients. If patients are not made better by antiinflammatories, then the next step is often what its called lumbar epidural steroid injections. These are a steroid, again, an antiinflammatory drug that’s injected directly into the spine. The risks of both of these kinds of treatments are very low, and the success rates though are in the 30-40% range, but that’s significant compared to not being made better at all.