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Peyronie’s Disease – Causes and Treatments

Medically reviewed by Steven N. Gange, MD, Susan Kerrigan, MD and Marianne Madsen on January 21, 2023

Perhaps understandably so, anything having to do with the penis can be a highly sensitive subject for most men. It is an important part of their being, and whether or not the penis is working properly can have a huge effect on a man’s life and ego.


It’s a shame that some men are reluctant to talk about this part of their lives because as with all parts of the body, there are several things that can go wrong with it–and most of them are highly treatable. It’s also important to talk about these things for mental health reasons because it erases the stigma of something being “wrong,” and lets men know that they are far from alone in experiencing these problems. They are also not alone in seeking help to treat these highly solvable problems.


Functions of the Penis


The penis has two primary functions for the male body. One is as a mechanism to help transport urine out of the body. This aspect may be purely functional and may not be so much fun, but it is quite necessary for the body to function properly. The second job of the penis is to transfer sperm into a mate’s body. Many men find this part much more enjoyable for obvious reasons. But what can go wrong with such a seemingly simple organ?


Peyronie’s Disease


Well, erectile dysfunction, for starters.  But did you know that you could have issues with your erection without having E.D.? According to the Urology Care Foundation, it is estimated that about 6 out of every 100 men in the ages between 40 and 70 have something called Peyronie’s disease.  Specifically, it is a buildup of plaque or scar tissue on the top part of the penis. This plaque can, in very advanced cases, also contain a build up of calcium which then solidifies so that it looks like another bone. When this build up of plaque happens, it can cause the penis to either bend or curve and create lumps. You may even experience soft or painful erections, which definitely puts a cramp in many men’s styles.


Causes of Peyronie’s Disease


If you have noticed one of these potentially major changes in the function of your penis, you may be wondering why and how this happened. Well, for starters, Peyronie’s is a scar from a minor injury to your penis that occurs during strenuous activity–almost always during sex. Most of the time when you get an injury, scar tissue forms over it which then will heal into regular skin. Peyronie’s disease is the result of that scar tissue not healing appropriately. 


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Sexual Health - Peyronie's Disease

Sexual Health - Peyronie's Disease

On the other hand, some men with Peyronie’s disease don’t seem to have experienced trauma during sex to the penis. This factor has led researchers to believe that there may be other reasons for it to occur. Some researchers think that vigorous athletic activities or even some type of accident may cause Peyronie’s disease.


Treatment of Peyronie’s Disease


First of all, it’s extremely important to go to a urologist the minute you see something is wrong–or right now, if you’ve noticed something that you’re ignoring. The internet may be a wealth of knowledge, but it is no substitute for the actual treatment plan a urologist will come up with specifically for you. Second, depending on how badly you’ve been affected by the disease, your urologist may suggest certain medications to help treat it. 


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Sexual Health - Peyronie's Disease - Treatment

Sexual Health - Peyronie's Disease - Treatment

Potassium amino-benzoate (“Potaba”) is part of the vitamin B complex that was shown to help reduce the size of the plaque, though it has not been shown to help treat the curve at all. Many men who are started on this treatment choose to stop it because of its cost and because it can cause stomach problems. 


A treatment plan that is a step up from investigative medications and potentially helpful vitamins are injections. The penis is numbed before insertion to reduce any pain that might be felt. A form of injection used to treat Peyronie’s disease is an injection of collagenase. This is something that is also created naturally in your body already and is what helps to break down certain types of tissues. There have been studies that have proven its effectiveness in treating Peyronie’s disease and has officially been approved by the FDA for men who have more than a 30 degree curve.


Other types of injections are still being tested. One type of injection is called Verapamil, and it is a low cost way to help treat the disease. While it is mostly used to treat high blood pressure, this injection has been shown to treat the actual pain and curving experienced with Peyronie’s disease. Another injection is called interferon, which is a protein that helps control swelling. More testing is needed to prove its effectiveness; however, it has shown promise by helping to slow down the rate at which the scar tissue builds and even help break it down.




Barring the effectiveness of these forms of treatments and depending on the severity of the disease, the last option left may be surgery to help fix the curve. However, your urologist will likely suggest holding off on this option until your plaque and curve have stopped getting worse and you have not had pain for at least nine months. But even with this option, there are a few possible types of surgery that could be done.


A surgery called “plication” is one of the simplest ways to work with Peyronie’s disease. During this procedure, the penis is erected with either an injection of saltwater solution or with selected medications. Then the outer skin of the penis is pulled back and the penis is straightened. The excess tissue from the outer side of the curve is plicated, or stitched together with a series of tucks. 


Another type of surgery is grafting tissue (either taken from somewhere else on your body or lab created) into the empty space created after removing any plaque or scar tissue. Yet another type of surgery is a bit more complicated and involves a prosthetic device that is inserted into the penis to help straighten it and get it stiff enough for more pleasurable activities. However, if the prosthetic alone doesn’t make it straight enough, the surgeon will then straighten it more by cutting into the plaque and placing a graft over the opening or by molding the plaque against the device to make it firmer.


You don’t have to suffer quietly with Peyronie’s disease–you have options. The hope is that spreading more information about Peyronie’s disease, how common it is, and the various options there are to treat it will make men less embarrassed about acknowledging the problem and prompt them to seek out help.




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